Reframing Hyaluronidase in Aesthetic Medicine: From “Dissolving Filler” to “Modifying Filler”

June 30, 2026

Aesthetic Surgery Journal

Authors: Steven Harris, MBBCh, MSc , Steven Weiner, MD

Summary: Hyaluronidase is often described as “dissolving” dermal filler, but this term oversimplifies how the enzyme actually interacts with long-standing filler within living tissue. This article explains why hyaluronidase more accurately modifies a complex filler–tissue system rather than completely eliminating filler, and why clearer terminology improves patient understanding, clinical decision-making, and ethical practice in aesthetic medicine.

JOURNAL ARTICLE

Journals | June 30, 2026

The Association Between Repeated Lip Augmentation With Hyaluronic Acid Filler and Recurrence of Herpes Labialis: A Longitudinal Self-controlled Study

Recurrent herpes labialis (RHL) is a common condition characterized by episodic viral reactivation triggered by local or systemic factors. Hyaluronic acid (HA) lip augmentation is widely performed for aesthetic purposes, yet its potential association with changes in herpes labialis recurrence has not been systematically evaluated. The aim of this study was to investigate whether repeated lip augmentation with HA filler is associated with changes in the incidence of RHL episodes over time.

Journals | June 30, 2026

Hyaluronic Acid Injection Techniques for Lip Augmentation—Comparison of Linear, Retrograde, and Microdeposit Approaches: A Systematic Review

Hyaluronic acid (HA) is widely used for lip augmentation; however, the safety and performance of injection techniques and instruments (needle vs cannula) remain unclear. The aim of this study was to evaluate the safety of HA injection techniques for lip augmentation and to assess patient satisfaction, injected volume, and associations with technique, instrument, and HA product.

Journals | June 30, 2026

Efficacy and Safety of IncobotulinumtoxinA for the Simultaneous Treatment of Upper Facial Lines: A GRADE Assessed Systematic Review and Meta-analysis

Upper facial lines (UFLs), including glabellar frown lines (GFLs), horizontal forehead lines (HFLs), and lateral canthal lines (LCLs) are prevalent aesthetic concerns addressed with botulinum neurotoxin type A (BoNT-A). IncobotulinumtoxinA, a highly purified BoNT-A formulation, is utilized for simultaneous UFLs treatment; yet, comprehensive synthesized evidence is limited.

Journals | June 30, 2026

Reframing Hyaluronidase in Aesthetic Medicine: From “Dissolving Filler” to “Modifying Filler”

Hyaluronidase is often described as “dissolving” dermal filler, but this term oversimplifies how the enzyme actually interacts with long-standing filler within living tissue. This article explains why hyaluronidase more accurately modifies a complex filler–tissue system rather than completely eliminating filler, and why clearer terminology improves patient understanding, clinical decision-making, and ethical practice in aesthetic medicine.

Journals | June 30, 2026

Effect of Botulinum Toxin Injection Intervals on the Irreversibility of Targeted Muscle Paralysis: An Electromyographic Study

Botulinum neurotoxin A (BoNT-A) is widely used clinically; yet, its temporary effects require repeated injections that increase cost and inconvenience. There is limited rigorous evidence to support claims that repeated BoNT-A use alters efficacy. Unlike peripheral nerve transection, which causes irreversible denervation after 12 to 24 months, the long-term physiological effects of BoNT-A chemodenervation remain unclear.

Reframing Hyaluronidase in Aesthetic Medicine: From “Dissolving Filler” to “Modifying Filler”

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